BMC Genomics - Volume 10, issue Preprint

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Electronic ISSN
1471-2164

Abstract

Background

Cotton (Gossypium hirsutum) is one of the most important economic crops and provides excellent fibers for textile manufacture. In addition to its industrial and agricultural importance, the fiber cell (plant trichome) also is a biological model system for exploring gene expressio

Journal: BMC Genomics, vol. 10, no. Preprint, 2009

Abstract

Background

Genome sequences can be conceptualized as arrangements of motifs or words. The frequencies and positional distributions of these words within particular non-coding genomic segments provide important insights into how the words function in processes such as mRNA stability and regulation

Journal: BMC Genomics, vol. 10, no. Preprint, 2009

Abstract

Background

The requirements for growth and survival of the intracellular pathogen Trypanosoma cruzi within mammalian host cells are poorly understood. Transcriptional profiling of the host cell response to infection serves as a rapid read-out for perturbation of host physiology that, in par

Journal: BMC Genomics, vol. 10, no. Preprint, 2009

Abstract

Background

The free-living nematode Caenorhabditis elegans makes a developmental decision based on environmental conditions: larvae either arrest as dauer larva, or continue development into reproductive adults. There is natural variation among C. elegans lines in the sensitivity of

Journal: BMC Genomics, vol. 10, no. Preprint, 2009

Abstract

Background

The recently developed RNA interference (RNAi) technology has created an unprecedented opportunity which allows the function of individual genes in whole organisms or cell lines to be interrogated at genome-wide scale. However, multiple issues, such as off-target effects or low efficaci

Journal: BMC Genomics, vol. 10, no. Preprint, 2009

Abstract

Background

The advent of high-throughput and cost-effective genotyping platforms made genome-wide association (GWA) studies a reality. While the primary focus has been invested upon the improvement of reducing genotyping error, the problems associated with missing calls are largely overlooked.

Journal: BMC Genomics, vol. 10, no. Preprint, 2009

Abstract

Background

Polycyclic aromatic hydrocarbons are common pollutants in soil, have negative effects on soil ecosystems, and are potentially carcinogenic. The Springtail (Collembola) Folsomia candida is often used as an indicator species for soil toxicity. Here we report a toxicogenomic study t

Journal: BMC Genomics, vol. 10, no. Preprint, 2009

Abstract

Background

Plasmodium parasites are causative agents of malaria which affects >500 million people and claims ~2 million lives annually. The completion of Plasmodium genome sequencing and availability of PlasmoDB database has provided a platform for systematic study of parasite gen

Journal: BMC Genomics, vol. 10, no. Preprint, 2009

Abstract

Background

Microsatellite loci are frequently used in genomic studies of DNA sequence repeats and in population studies of genetic variability. To investigate the effect of sequence properties of microsatellites on their level of variability we have analyzed genotypes at 627 microsatellite loci in

Journal: BMC Genomics, vol. 10, no. Preprint, 2009

Abstract

Background

Motor proteins have extensively been studied in the past and consist of large superfamilies. They are involved in diverse processes like cell division, cellular transport, neuronal transport processes, or muscle contraction, to name a few. Vertebrates contain up to 60 myosins and about

Journal: BMC Genomics, vol. 10, no. Preprint, 2009