BMC Bioinformatics - Volume 12, issue Suppl 1

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Electronic ISSN
1471-2105

Abstract

Background

Beta-site amyloid precursor protein cleaving enzyme (BACE-1) is a single-membrane protein belongs to the aspartyl protease class of catabolic enzymes. This enzyme involved in the processing of the amyloid precursor protein (APP). The cleavage of APP by BACE-1 is the rate-limiting step i

Journal: BMC Bioinformatics, vol. 12, no. Suppl 1, 2011

Abstract

Background

To understand the gene regulatory system that governs the self-renewal and pluripotency of embryonic stem cells (ESCs) is an important step for promoting regenerative medicine. In it, the role of several core transcription factors (TFs), such as Oct4, Sox2 and Nanog, has been intensivel

Journal: BMC Bioinformatics, vol. 12, no. Suppl 1, 2011

Abstract

Background

Ancestral Recombinations Graph (ARG) is a phylogenetic structure that encodes both duplication events, such as mutations, as well as genetic exchange events, such as recombinations: this captures the (genetic) dynamics of a population evolving over generations.

Results

In this pape

Journal: BMC Bioinformatics, vol. 12, no. Suppl 1, 2011